{"id":1959,"date":"2021-09-09T10:37:00","date_gmt":"2021-09-09T06:07:00","guid":{"rendered":"http:\/\/khademi.me\/?p=1959"},"modified":"2024-07-20T11:28:19","modified_gmt":"2024-07-20T07:58:19","slug":"can-you-inject-without-the-needle","status":"publish","type":"post","link":"https:\/\/pharmex.me\/en\/2021\/09\/09\/can-you-inject-without-the-needle\/","title":{"rendered":"Can You Inject Without the Needle?"},"content":{"rendered":"\r\n<p class=\"has-text-align-left wp-block-paragraph\"><strong>A Pharmapack 2018 speaker explains a new needle-free approach that could suit biologics and support digital health.<\/strong><\/p>\r\n\r\n\r\n\r\n<p class=\"has-text-align-left wp-block-paragraph\">Patients aren\u2019t typically thrilled by the prospect of needles, and sharps can pose hazards for patients and caretakers. So, could an injectable device be developed without a needle?<\/p>\r\n\r\n\r\n\r\n<p class=\"has-text-align-left wp-block-paragraph\">Andrew Coats, senior director of engineering at Portal Instruments, will be exploring the possibilities in the upcoming\u00a0<a href=\"https:\/\/www.pharmapackeurope.com\/agenda?title_field_value=&amp;field_related_speaker_target_id_entityreference_filter_1=All&amp;field_session_topic_tid_selective=78&amp;field_session_type_tid_selective=All\">Pharmapack 2018<\/a>\u00a0presentation, \u201cNeedle-free injectors: considerations for adopting next gen technology.\u201d Portal has developed a needle-free injector based off jet-injector technology, which is essentially a high-speed jet of drug that is much smaller than a needle and can deliver up to 1 mL to the subcutaneous space, the company reported.<\/p>\r\n\r\n\r\n\r\n<p class=\"has-text-align-left wp-block-paragraph\">Single- and multi-lumen tubing, co-extrusions, bump tubing, profile and micro-extrusions, coated wire, tri-extrusions, multi-layered extrusions, fully encapsulated stripes, over-extrusions, balloon tubing, ribbon extrusions, intermittent extrusions, and new concepts.<\/p>\r\n\r\n\r\n\r\n<p class=\"has-text-align-left wp-block-paragraph\">&#8220;The rise of biologics to treat chronic conditions and the push for home administration means more people are taking medication on a regular basis, in their home,\u201d Coats told\u00a0<em>MD+DI<\/em>. \u201cSince the chemical structure of biologics makes them extremely susceptible to the harsh conditions of the gastrointestinal tract, subcutaneous injections via an IV or in-home injection is often the standard delivery method.\u201d<\/p>\r\n\r\n\r\n\r\n<p class=\"has-text-align-left wp-block-paragraph\">However, fear of needles can interfere with administration and ultimately patient compliance. \u201cNeedle anxiety along with needle phobia is quite prevalent and is documented to be experienced by both children and adults,\u201d he said.\u00a0<sup>1, 2, 3<\/sup>\u00a0\u201cNeedle anxiety and phobia can result in a host of deleterious consequences, including vaccination non-compliance and avoidance of healthcare.\u201d<sup>1, 2<\/sup><\/p>\r\n\r\n\r\n\r\n<p class=\"has-text-align-left wp-block-paragraph\">For instance, a 2012 survey showed that \u201c20% of RA sufferers report that they would not consider using a medication that required self-injection,\u201d he pointed out.\u00a0<sup>3<\/sup>\u00a0\u201cNeedle anxiety goes beyond physical pain. Some patients dislike the stigma of sickliness associated with needle usage, while others are afraid of not being able to properly self-administer injections. Parents living with children in the household also fear that children may accidentally stumble across a needle-based device and hurt themselves.\u201d<\/p>\r\n\r\n\r\n\r\n<p class=\"has-text-align-left wp-block-paragraph\">Alternatives to needles could bypass such fear. \u201cPortal believes we can answer this challenge by removing the needle and by connecting the device to our digital health platform to provide reminders, coaching, and communication, all leading to a better overall experience,\u201d Coats said.<\/p>\r\n\r\n\r\n\r\n<p class=\"has-text-align-left wp-block-paragraph\">Portal\u2019s approach is a next-generation, needle-free injector, he explained. \u201cWhat is unique about the Portal system is that it uses a computer-controlled linear actuator to pressurize the medication and inject it in a very fine liquid stream (about the size of a strand of hair). The entire injection takes less than half a second. The algorithms within the device allow for injections at a specific depth within tissue, and the release of medication is precisely controlled during the injection process\u2014fast at first and then slow.\u201d<\/p>\r\n\r\n\r\n\r\n<p class=\"has-text-align-left wp-block-paragraph\">Other attempts to eliminate the needle have been made, but Coats pointed\u00a0to concerns. \u201cHistorically, needle-free devices used a mechanical means (e.g., a high-powered spring, compressed air, or gas cartridges like CO2 or Nitrogen) to generate the needed energy to inject the shot,\u201d said Coats. \u201cUnfortunately, it also sounded like an \u2018explosion\u2019 and left patients feeling like they got punched.\u201d<\/p>\r\n\r\n\r\n\r\n<p class=\"has-text-align-left wp-block-paragraph\">And there\u2019s another concern with injecting biologics. \u201cA key consideration in the development of formulations for subcutaneous administration is the limited volume (1 to 2 mL) available in the subcutaneous space\u00a0<sup>4, 5<\/sup>, which calls for the development of highly concentrated, stable formulations of medications intended for subcutaneous delivery,\u201d he said.\u00a0<sup>4<\/sup>\u00a0\u201cThis introduces a difficult drug delivery challenge&#8211;at high concentrations of drugs (&gt;100 mg\/ mL), the viscosity of formulation increases exponentially.<sup>6<\/sup>\u00a0In addition, biologic drugs need to be stored at temperatures between 2 to 8 \u00b0C and these low temperatures result in an additional increase in drug viscosity.<sup>6<\/sup>\u00a0This unique relationship between concentration, temperature, and viscosity introduces a set of specific requirements for any drug delivery mechanism employed. Common problems reported with subcutaneous injectors include the high force requirements to eject highly viscous formulations and a prolonged injection time.\u201d<\/p>\r\n\r\n\r\n\r\n<p class=\"wp-block-paragraph\">&nbsp;<\/p>\r\n","protected":false},"excerpt":{"rendered":"<p>A Pharmapack 2018 speaker explains a new needle-free approach that could suit biologics and support digital health. Patients aren\u2019t typically thrilled by the prospect of needles, and sharps can pose hazards for patients and caretakers. So, could an injectable device be developed without a needle? Andrew Coats, senior director of engineering at Portal Instruments, will [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1960,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1959","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pharmex-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Can You Inject Without the Needle? - Pharmex<\/title>\n<meta name=\"description\" content=\"Patients aren\u2019t typically thrilled by the prospect of needles, and sharps can pose hazards for patients and caretakers.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharmex.me\/en\/2021\/09\/09\/can-you-inject-without-the-needle\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Can You Inject Without the Needle? 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